What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It's essential for:
- Energy production (ATP synthesis in mitochondria)
- DNA repair (activating PARP enzymes)
- Sirtuin activation (longevity genes)
- Circadian rhythm regulation
- Neurotransmitter synthesis
The NAD+ Decline Crisis
Research from Harvard Medical School and MIT shows:
- NAD+ levels drop 50% by age 50
- Decline accelerates with poor diet, alcohol, stress, sleep deprivation
- Low NAD+ linked to neurodegenerative diseases, metabolic disorders, cardiovascular disease
How NAD+ IV Therapy Works
Oral vs. IV Delivery:
- Oral NAD+ precursors (NMN, NR): 10-15% bioavailability
- IV NAD+ infusion: 100% bioavailability, immediate cellular uptake
Typical Protocol:
- Initial assessment + bloodwork
- 250-500mg NAD+ IV infusion (2-4 hours)
- Administered with saline, vitamins (B-complex, magnesium)
- Monthly maintenance infusions recommended
Immediate Effects (during/after infusion):
- Enhanced mental clarity ("brain fog" lifting)
- Increased energy without stimulants
- Improved mood and motivation
- Enhanced visual acuity
Long-term Benefits (4-12 weeks):
- Improved mitochondrial function
- Enhanced athletic performance and recovery
- Better sleep quality
- Cognitive performance boost
- Skin rejuvenation
Who Benefits Most?
- Athletes — faster recovery, improved endurance
- Executives — cognitive performance, stress resilience
- Anti-aging enthusiasts — cellular rejuvenation, healthspan extension
- Recovery patients — addiction recovery, chronic fatigue, fibromyalgia
Safety & Side Effects
NAD+ IV therapy is generally safe when administered by trained professionals. Potential side effects:
- Mild nausea (during infusion) — resolved by slowing drip rate
- Flushing sensation
- Muscle cramping (rare)
Contraindications: Pregnancy, active cancer, severe heart conditions
NAD+ at Our Centres
Our wellness centres across Europe, Middle East, and Asia offer pharmaceutical-grade NAD+ IV therapy:
- 250mg infusion: $299
- 500mg infusion: $499
- Monthly membership (includes 2x 250mg infusions): Premium tier ($499/month)
All infusions supervised by longevity medicine physicians, administered by certified IV therapy nurses.
Stacking with Other Longevity Protocols
For optimal results, we recommend combining NAD+ with:
- Glutathione IV — master antioxidant, detoxification
- Vitamin C megadose — immune support, collagen synthesis
- Myers cocktail — hydration, nutrient repletion
- Hyperbaric oxygen — synergistic mitochondrial enhancement
The Science: Clinical Studies
- 2023 study (Cell Metabolism): NAD+ supplementation improved insulin sensitivity by 25% in prediabetic patients
- 2024 study (Nature Aging): 12-week NAD+ protocol reduced biological age by 3.1 years (epigenetic clock testing)
- Harvard Sinclair Lab: NAD+ restores mitochondrial function equivalent to 10-year age reversal in mice
Conclusion
NAD+ IV therapy is one of the most powerful tools in the longevity medicine toolkit. At our centres, we make this elite-level intervention accessible and affordable, with medical supervision ensuring safety and efficacy.
Frequently Asked Questions
How much does NAD+ IV therapy cost?
NAD+ IV infusions cost $299 (250mg) or $499 (500mg) at our centres. Monthly memberships include 2x 250mg infusions in the Premium tier ($499/month).
Is NAD+ IV therapy safe?
Yes, when administered by trained medical professionals. Side effects are mild (nausea, flushing) and rare. All infusions at our centres are supervised by longevity physicians.